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By Moore R. L.

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To some, genetics is a subfield of genomics; to others, genomics is a subfield of genetics. Arguably, depending on the perspective one has in mind, both may be right! Here, we provide operational definitions to distinguish the various terms and the subfields of medicine to which they contribute. The field of genetics is the scientific study of heredity and of the genes that provide the physical, biological, and conceptual bases for heredity and inheritance. To say that something – a trait, a disease, a code, or information – is “genetic” refers to its basis in genes and in DNA.

Notwithstanding the above findings about common variation, it is true that the majority of variable sites in the genome are rare, not common, and private to specific populations rather than ancient and shared among populations. These patterns of variation reflect an explosion of population growth from an ancestral population of likely less than 10,000 individuals, with Eurasians diverging from an ancestral African population an estimated 38–64,000 years ago, shaped by various patterns of migration around the globe, both ancient and continuing to within just the last few generations.

2). 1d). 1). 2). , 2007). 3). While the overall estimate of SNP heterozygosity is approximately 1 in 1500 basepairs, there is much more variation in non-coding sequences than in the coding segments of genes, reflecting strong selective pressure during evolution against certain types of change in gene sequences. The combination of particular alleles along chromosomes is also non-random, with particular combinations (haplotypes) being more prevalent over short distances, due to the relative inefficiency of meiotic recombination to separate alleles at sites that are physically close together (International HapMap Consortium, 2007).

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Concerning Paths That Do Not Separate a Given Continuous Curve by Moore R. L.


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