Download e-book for kindle: Combinatorial Chemistry, 2nd Ed. by Bannwarth W., Hinzen B.

By Bannwarth W., Hinzen B.

ISBN-10: 3527306935

ISBN-13: 9783527306930

"This progressive technique permits natural and medicinal chemists to synthesize hundreds of thousands or maybe thousands of doubtless attention-grabbing compounds in one response series. mixed with present tools of excessive throughput research, combinatorial equipment have nearly thoroughly changed the normal step by step synthesis of power drugs." "Retaining its practice-oriented procedure, this new version has been completely up to date to mirror advancements in parallel synthesis, whereas a brand new bankruptcy on screening enhances the evaluate of combinatorial technique and artificial tools. the result's a instruction manual adapted to the desires of the undefined, with just about all the authors affiliated with top pharmaceutical companies."--BOOK JACKET. learn more... content material: Purification ideas in high-speed solution-phase synthesis / Steffen Weinbrenner, C. Christoph Tzschucke -- Linkers for solid-phase natural synthesis (SPOS) and combinatorial methods on reliable helps / Willi Bannwarth -- Cyclative cleavage : a flexible idea in solid-phase natural chemistry / Josef Pernerstorfer -- C-C bond-forming reactions / Wolfgang K.-D. Brill, Gianluca Papeo -- Combinatorial synthesis of heterocycles / Eduard R. Felder, Andreas L. Marzinzik -- Polymer-supported reagents : guidance and use in parallel natural synthesis / Berthold Hinzen, Michael G. Hahn -- Encoding ideas for combinatorial libraries / Berthold Hinzen -- Automation and units for combinatorial chemistry and parallel natural synthesis / Christian Zechel -- Computer-assisted library layout / Andreas Dominik -- Assays for high-throughput screening in drug discovery / Christian M. Apfel, Thilo Enderle. summary: Combinatorial chemistry is a innovative process, which lets you synthesize thousands of compounds inside of a couple of steps and in a truly brief period of time. hundreds of thousands of goods, e.g. strength medicines, may be analyzed in a single cross, so you understand very quickly if one or a number of components on your product combination express organic task. learn more...

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Extra info for Combinatorial Chemistry, 2nd Ed.

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Examples of fluorous transition metal complexes are shown in Fig. 3. Fluorous-tagged reagents are very attractive for reactions in which a stoichiometric by-product is formed that is difficult to separate. An example is perfluoroalkylated triphenylphosphane for use in Wittig and aza-Wittig reactions, where the corresponding phosphane oxide is removed by fluorous extraction [22, 23]. Similarly, fluorous sulfoxide has been employed in Swern oxidations, and fluorous carbodiimide has been used as a coupling reagent [24, 25].

1 Silica Gel and Alumina A large variety of inorganic salts can be very easily removed by SPE with silica gel or alumina as in an aqueous work-up. Furthermore, it is possible to separate amine hydrochlorides or even an excess of amine or acid from the desired product by silica gel or alumina SPE. Even reagents (e. , the coupling agent EDC) can be separated by simple filtration of the reaction mixture through silica gel or alumina (Scheme 7). 3 Solid-Phase Extraction Scheme 7 A large number of polar reagents, side products, and impurities that are removable by aqueous work-up can also be separated by SPE with alumina or silica gel, and therefore SPE based on these adsorbents offers an easily automated and inexpensive alternative to aqueous work-up.

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Combinatorial Chemistry, 2nd Ed. by Bannwarth W., Hinzen B.


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