By H. Rheinberger
With the increase of genomics, the existence sciences have entered a brand new period. This ebook offers a entire historical past of mapping methods as they have been built in classical genetics. An accompanying quantity - From Molecular Genetics to Genomics - covers the background of molecular genetics and genomics.The ebook exhibits that the expertise of genetic mapping is in no way a up to date acquisition of molecular genetics or maybe genetic engineering. It demonstrates that the advance of mapping applied sciences has followed the increase of recent genetics from its very beginnings. In part One, Mendelian genetics is determined in point of view from the perspective of the detection and outline of linkage phenomena. part addresses the function of mapping for the experimental operating perform of classical geneticists, their social interactions and for the laboratory 'life worlds'.With designated analyses of the clinical practices of mapping and its representation of the variety of mapping practices this booklet is an important contibution to the historical past of genetics. A better half quantity from a similar editors - From Molecular Genetics to Genomics: The Mapping Cultures of 20th Century Genetics - covers the background of molecular genetics and genomics.
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Additional info for Classical Genetic Research and Its Legacy: The Mapping Cultures of Twentieth Century Genetics (Studies in the History of Science, Technology and Medicine, 19)
This model easily explained the transmission process in the case of a single character pair where each germ cell came to carry only one of the two Anlagen. At the same time it nicely explained why, as in the case of Matthiola, a whole set of characters could be passed on together in a coupled fashion with the same original combination of characters as received from the father and the mother, respectively. This was the “zygolytic” reduction-division. 3. The result was a statistical redistribution of the Anlagen on the different halves of the chromosomes, amounting to a recombination of the characters received from mother and father, respectively.
Baur, E. (1932) “Konsequenzen der Vererbungslehre für die Pflanzenzüchtung,” Handbuch der Vererbungswissenschaft, IIID: 1–30. Beseler, O. (1904) “Über Pflanzenzucht und deren Ausnutzung durch die Praxis,” Fühlings Landwirtschaftliche Zeitung, 53: 689–95. , and Zallen, D. (1988) “The Singular Fate of Genetics in the History of French Biology, 1900–1940,” Journal of the History of Biology, 21: 357–402. Cuenot, L. (1904) “Les recherches experimentales sur l’hérédité mendelienne,” Revue generale des Sciences pures et appliquées, 15: 303–10.
Linkage before Mendelism? 17 Similarly, pleiotropy enabled Mendelians to ascribe apparent correlations, not to a complex relation between several traits, but merely to a single gene with multiple effects. e. the absence of certain combinations), not in terms of physiological compensation, but rather in terms of an additional gene that killed the embryo at an early stage. As is well known, the essentially reductionist nature of these stratagems did not satisfy all sections of the biological community.
Classical Genetic Research and Its Legacy: The Mapping Cultures of Twentieth Century Genetics (Studies in the History of Science, Technology and Medicine, 19) by H. Rheinberger