By William B. Guggino (Eds.)
The volume of latest details at the molecular biology of chloride channels has grown drastically in recent times. this massive quantity of data supplies a few exact and, in a few circumstances, remarkable insights into the functionality and constitution of chloride channels that are found in each telephone. This quantity includes a sequence of in-depth studies of chloride channel body structure, biophysics, and molecular biology. The reports hide chloride channels present in the plasma membrane in addition to in organelles of either plant and animal cells. Key positive aspects* Discusses CFTR, the cystic fibrosis transmembrane regulator, that is accountable for CF and the CIC-family of chloride channels chargeable for myotonia congenita* In-depth experiences of chloride channel body structure, biophysics, and molecular biology* studies chloride channels present in the plasma membrane and in organelles of either plant and animal cells
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Additional resources for Chloride Channels
2a). This leads to maximum steadystate currents in the range between -80 and - 120 mV. This is similar to results obtained earlier with the T . , 1984). It is also consistent with the studies of Miller and colleagues (Richard and Miller, 1990) on the reconstituted T . californica channel. It slowly activates within seconds with negative voltage on the cis side of the bilayer; once activated, the current increases (fast) with positive voltages. Comparison of these voltage dependences strongly suggests that the cis side of the bilayer corresponds to the cytoplasmic side of ClC-0.
S . A . 89, 2466-2470. Raschke, K. (1970). Stomata1 responses to pressure changes and interruptions in the water supply of detached leaves of Zea mays L. Plant Physiol. 45, 415-423. Raschke, K . (1979). Movements using turgor mechanisms. Encycl. , New Ser. 7, pp. 383-441. , and Hedrich, R. (1990). Patch-clamp measurements on isolated guard-cell protoplasts and vacuoles. I n “Methods in Enzymology” (S. Fleischer and B. ). Vol. 174, pp. 312-330. Academic Press, San Diego. Redhead, C. , Edelman, A.
Cytoplasmic calcium regulates voltage-dependent ion channels in plant vacuoles. Nature (London) 329, 833-836. Hedrich. R.. and Schroeder, J . I . (1989). The physiology of ion channels and electrogenic pumps in higher plants. Annu. Rev. Plant Physiol. 40, 539-569. , Schroeder, J. , and Fernandez, J. M. (1986). Patch-clamp studies o n higher plants: A perspective. Trends Biochem. Sci. 12, 49-52. Hedrich, R.. , and Raschke, K. (1990). Ca’+ and nucleotide dependent regulation of voltage dependent anion channels in the plasma membrane of guard cells.
Chloride Channels by William B. Guggino (Eds.)