By Christoph Wagener, Carol Stocking, Oliver Müller
Melanoma, which has develop into the second-most regularly occurring wellbeing and fitness factor globally, is basically a malfunction of phone signaling. knowing how the complex signaling networks of cells and tissues let melanoma to thrive - and the way they are often changed into effective guns opposed to it - is the major to coping with melanoma within the health facility and bettering the end result of melanoma remedies. of their ground-breaking textbook, the authors offer a compelling tale of ways melanoma works at the molecular point, and the way designated remedies utilizing kinase inhibitors and different modulators of signaling pathways can include and at last therapy it.
the 1st a part of the e-book offers an advent into the phone and molecular biology of melanoma, targeting the foremost mechanisms of melanoma formation. the second one a part of the ebook introduces the most signaling transduction mechanisms answerable for carcinogenesis and compares their functionality in fit as opposed to melanoma cells. unlike the complexity of its subject, the textual content is straightforward to learn. 32 specifically ready instructing movies on key options and pathways in melanoma signaling can be found on-line
Read Online or Download Cancer Signaling: from molecular biology to targeted therapy PDF
Best cell biology books
Книга The Genetics and Molecular Biology of Neural Tumors The Genetics and Molecular Biology of Neural TumorsКниги English литература Автор: Avery A. Sandberg , John F. Stone Год издания: 2008 Формат: pdf Издат. :Humana Press Страниц: 404 Размер: 22,6 ISBN: 1934115584 Язык: Английский0 (голосов: zero) Оценка:Collecting an intensive quantity of knowledge from hundreds of thousands of courses through prime investigators during this speedily constructing box, The Genetics and Molecular Biology of Neural Tumors offers a handy and updated one quantity resource for learn in neural tumors of assorted mobile origins.
This e-book has compatible intensity and assurance, nice for an individual that feels that Lewin's GENES is just too long. It has first-class reference lists for person who desires to understand extra. It has transparent diagrams and was once written elegantly. but it isn't really up-to-date often.
This new quantity of equipment in Enzymology keeps the legacy of this leading serial with caliber chapters authored by means of leaders within the box. this can be the 3rd of 3 volumes on hydrogen peroxide and mobilephone signaling, and comprises chapters on such themes because the organic chemistry of hydrogen peroxide, reactive oxygen species within the activation of MAP kinases, and investigating the position of reactive oxygen species in regulating autophagy.
Biochemistry: The Chemical Reactions of dwelling Cells, moment variation offers a competent resource of knowledge concerning the interesting chemical reactions happening within the human physique and within the dwelling global round us. Enlarged, up-to-date, and superior, this moment variation, just like the first, may be commonly considered as the main entire of all biochemistry texts.
- Human Drug Metabolism: An Introduction
- Anatomy, Histology, and Cell Biology PreTest Self-Assessment and Review, Third Edition (PreTest Basic Science)
- Reconstituting the Cytoskeleton
- Angiogenesis Protocols
- RNA-Ligand Interactions, Part B
Additional info for Cancer Signaling: from molecular biology to targeted therapy
Such a pathway fulﬁlls two major functions. First, it modulates the intensity of the originally extracellular signal. It can amplify, weaken, or extinguish the signal. Secondly, the pathway converts the signal into a form that allows and also prepares the cellular response. Examples for potential responses are proliferation, migration, diﬀerentiation, and apoptosis. It has to be noted that a signal can be transferred not only by the presence of a molecule but also by its absence. For example, normal cells react to the absence of growth factors by activation of signal transduction pathways that activate apoptosis.
Considering a constant mutation rate per nucleotide, there is a close relation between the number of cell divisions and the number of cells hit by mutations. Mutation rates can also be accelerated by environmental factors, including exposure to chemical carcinogens and radiation. If a mutation is causally involved in the initiation or in the progression of a tumor, it is called a driver mutation. Some driver mutations may be essential for the entire course of the disease; other driver mutations may confer a growth advantage only at certain stages of the disease.
In the 1960s and 1970s, several technologies were established, including analysis of genes suppressed by X-inactivation, immunoglobulin production by B-cells, or abnormal chromosomal karyotypes, which could be used to study mosaicism (Fialkow, 1976). Although such approaches were not applicable to all cancer types or patient samples, they provided compelling evidence of the clonal nature of cancers. A few key examples are presented as follows. Immunoglobulin (Ig) production was the ﬁrst mosaic system used to determine the clonal origin of a tumor.
Cancer Signaling: from molecular biology to targeted therapy by Christoph Wagener, Carol Stocking, Oliver Müller