Get Cancer Signaling: from molecular biology to targeted therapy PDF

By Christoph Wagener, Carol Stocking, Oliver Müller

ISBN-10: 3527336583

ISBN-13: 9783527336586

ISBN-10: 352780045X

ISBN-13: 9783527800452

ISBN-10: 3527800468

ISBN-13: 9783527800469

ISBN-10: 3527800484

ISBN-13: 9783527800483

Melanoma, which has develop into the second-most regularly occurring wellbeing and fitness factor globally, is basically a malfunction of phone signaling. knowing how the complex signaling networks of cells and tissues let melanoma to thrive - and the way they are often changed into effective guns opposed to it - is the major to coping with melanoma within the health facility and bettering the end result of melanoma remedies. of their ground-breaking textbook, the authors offer a compelling tale of ways melanoma works at the molecular point, and the way designated remedies utilizing kinase inhibitors and different modulators of signaling pathways can include and at last therapy it.
the 1st a part of the e-book offers an advent into the phone and molecular biology of melanoma, targeting the foremost mechanisms of melanoma formation. the second one a part of the ebook introduces the most signaling transduction mechanisms answerable for carcinogenesis and compares their functionality in fit as opposed to melanoma cells. unlike the complexity of its subject, the textual content is straightforward to learn. 32 specifically ready instructing movies on key options and pathways in melanoma signaling can be found on-line

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Example text

Such a pathway fulfills two major functions. First, it modulates the intensity of the originally extracellular signal. It can amplify, weaken, or extinguish the signal. Secondly, the pathway converts the signal into a form that allows and also prepares the cellular response. Examples for potential responses are proliferation, migration, differentiation, and apoptosis. It has to be noted that a signal can be transferred not only by the presence of a molecule but also by its absence. For example, normal cells react to the absence of growth factors by activation of signal transduction pathways that activate apoptosis.

Considering a constant mutation rate per nucleotide, there is a close relation between the number of cell divisions and the number of cells hit by mutations. Mutation rates can also be accelerated by environmental factors, including exposure to chemical carcinogens and radiation. If a mutation is causally involved in the initiation or in the progression of a tumor, it is called a driver mutation. Some driver mutations may be essential for the entire course of the disease; other driver mutations may confer a growth advantage only at certain stages of the disease.

In the 1960s and 1970s, several technologies were established, including analysis of genes suppressed by X-inactivation, immunoglobulin production by B-cells, or abnormal chromosomal karyotypes, which could be used to study mosaicism (Fialkow, 1976). Although such approaches were not applicable to all cancer types or patient samples, they provided compelling evidence of the clonal nature of cancers. A few key examples are presented as follows. Immunoglobulin (Ig) production was the first mosaic system used to determine the clonal origin of a tumor.

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Cancer Signaling: from molecular biology to targeted therapy by Christoph Wagener, Carol Stocking, Oliver Müller


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