By Neale Ridgway, Roger McLeod
Biochemistry of Lipids: Lipoproteins and Membranes, quantity Six, includes concise chapters that hide a large spectrum of issues within the box of lipid biochemistry and phone biology. It offers an enormous bridge among broad-based biochemistry textbooks and extra technical study guides, supplying cohesive, foundational details.
It is a invaluable instrument for complex graduate scholars and researchers who're drawn to exploring lipid biology in additional aspect, and comprises overviews of lipid biology in either prokaryotes and eukaryotes, whereas additionally delivering primary historical past at the next descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of advanced phospholipids, sphingolipids, and their structural versions. additionally coated are sections on how bioactive lipids are fascinated by phone signaling with an emphasis on sickness implications and pathological consequences.
- Serves as a normal reference ebook for scientists learning lipids, lipoproteins and membranes and as a sophisticated and up to date textbook for lecturers and scholars who're acquainted with the fundamental strategies of lipid biochemistry
- References from present literature can be incorporated in every one bankruptcy to facilitate extra in-depth study
- Key strategies are supported by means of figures and types to enhance reader understanding
- Chapters offer old standpoint and present research of every topic
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Extra info for Biochemistry of Lipids, Lipoproteins and Membranes, Sixth Edition
Similar organisation of aromatic amino acids of α-helical proteins near the membrane interface region has been observed in other membrane proteins and may be involved in π-bonding interactions with the head groups of lipids. 3 Organisation of Protein Complexes Rather than being associated with the exterior surface of membrane proteins, many phospholipids are found wedged between the subunits of oligomeric complexes. Anionic phospholipids have a particularly important function in energy-transducing membranes, such as the bacterial cytoplasmic membrane and the inner mitochondrial membrane.
The ATP-bound form of MinD has high affinity for anionic phospholipids. Interaction of MinD with MinE results in ATP hydrolysis and release of MinD from the membrane. MinE also interacts with membrane phospholipids through its N-terminal domain, which can form an amphipathic α-helix. ATP binding and hydrolysis cause the rapid movement of MinD from one cell pole to the opposite cell pole, by alternately forming membrane-associated zones of coiled oligomeric MinD structures extending from each pole.
Approaches to Lipid Analysis Chapter | 2 43 three categories – fatty acids, simple lipids and complex lipids. Fatty acids from plant and animal origin have different properties. Fatty acids of animal origin are summarised in several subcategories – cis/trans, saturated, mono- or polyunsaturated. Plant fatty acids are more complex and may contain different functionalities, including epoxy-, hydroxy- and keto- groups. Bacterial fatty acids can contain branched, odd-carbon or cyclopropane groups (the synthesis and metabolism of these fatty acids is described in Chapters 3–6).
Biochemistry of Lipids, Lipoproteins and Membranes, Sixth Edition by Neale Ridgway, Roger McLeod