By Qin Wang
This quantity of present themes in Membranes specializes in Adrenergic Receptor Biology, starting with a evaluation of earlier successes and old views then extra discussing present normal developments in adrenic receptor reviews in a variety of contexts. This ebook additionally comprises discussions of the position and courting of adrenergic receptors to various platforms and ailments, constructing Adrenergic Receptor Biology as a wanted, useful reference for researchers.
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Extra info for Advances in Adrenergic Receptor Biology
Organizational Complexity of b-adrenergic Receptor Signaling Systems 27 obvious and suggest ways that different ligands might actually stabilize distinct receptor conformations – coupled to specific signaling pathways. We will return to this notion in a broader context at the end of this chapter. Certainly, this will lead to a refined development of more ‘‘selective’’ ligands at the pathway level. We are still avidly awaiting agonist-bound structures of different GPCRs as well as the receptor complexed with G proteins and other interacting partners.
Since then, it has become clear that each receptor interacts with a wide array of signaling pathways (Fig. 1), some of which depend directly on G protein-dependent signaling and others which involve agonist-dependent recruitment of G protein-coupled receptor kinases (GRKs) and b-arrestins (reviewed in Luttrell & Gesty-Palmer, 2010). Once believed to be primarily involved in the desensitization and internalization of GPCRs, it has become clear that b-arrestin-dependent signaling events enrich both the phenotypic diversity of signaling and also deliver receptor-dependent signals to distinct subcellular targets.
Barak, L. S. (2000). Differential affinities of visual arrestin, b arrestin1, and b arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem, 275, 17201–17210. , & Schramm, M. (1976). Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion. Proc Natl Acad Sci USA, 73, 4410–4414. , & Chabre, M. (1983). Interaction between photoexcited rhodopsin and peripheral enzymes in frog retinal rods. Influence on the postmetarhodopsin II decay and phosphorylation rate of rhodopsin.
Advances in Adrenergic Receptor Biology by Qin Wang