Read e-book online Acute Exposure Guideline Levels for Selected Airborne PDF

By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

ISBN-10: 030908511X

ISBN-13: 9780309085113

ISBN-10: 0309567734

ISBN-13: 9780309567732

File from the Subcommittee on Acute publicity guide degrees and the Committee on Toxicology from the Board on Environmental stories and Toxicology. quantity 2. Softcover.

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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2

Example text

1994). 18 mg/m3) (Lipsett et al. 1994). Phosgene is manufactured from a reaction of carbon monoxide and chlorine gas in the presence of activated charcoal. Manufacture of phosgene is approximately 1 million tons per year (y) in the United States, and more than 10,000 workers are involved in its manufacture and use (Currie et al. 1987a). Manufacture of phosgene in the United States is almost entirely captive (more than 99% is used in the manufacture of other chemicals within a plant boundary). S.

Number/ Exposure Concentration End Reference Strain Gender Time (min) (ppm) Point NR NR 20 37 LC100 Rothlin 1941 NR NR 30 22 LC100 Winternitz et al. 1920 NR, not reported. 6. Dogs Meek and Eyster (1920) exposed eight mongrel dogs (gender not specified) to phosgene at 80–100 ppm for 30 min. All eight died within 24 h postexposure. Pulmonary edema with some evidence of cardiac effects was observed at necropsy. Additional dog lethality information is presented in Table 1–10. 7. Goats Karel and Weston (1947) reported a 10-min LC50 of 250 ppm for a group of 30 female and 1 male goat, and Underhill (1920) reported a 15-min LC50 of 180 ppm for a group of 61 goats.

NIOSH (1976) compared the medical records of 326 workers exposed to phosgene with those of 6,288 unexposed workers from the same plant. 003 ppm. 14 ppm in 5 of 56 samples. There were no differences in pulmonary function or deaths attributable to respiratory disease between the exposed and control populations. 3. Developmental and Reproductive Toxicity Developmental and reproductive studies regarding acute human exposure to phosgene were not available. 4. Genotoxicity Genotoxic studies regarding acute human exposure to phosgene were not available.

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Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2 by National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels


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