By Karsten Schrör
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Extra resources for Acetylsalicylic Acid
3) . 3 In vitro release kinetics of ASA under standard conditions from commercially available ASA preparations in Germany . -B. -B. -B. -B. -B. -B. 9 According to predeﬁned quality standards, the content of the active ingredient should be 95–105% of declaration and at least 80% of the compound should be released within 30 min under the conditions chosen. References The authors repeated this study 2 years later on 62 different aspirin preparations. ) still did not meet the quality standards mentioned above .
3) have tainted its reputation and resulted in its removal from the list of essential drugs by the WHO in 1988. 1) – and the subsequent meta-analyses by the Antiplatelet Trialists Collaboration were published and showed a signiﬁcant reduction of the incidence of myocardial infarction or other atherothrombotic events in both healthy volunteers and patients at elevated cardiovascular risk . The ISIS-2 study of 1989 convincingly demonstrated for the ﬁrst time a signiﬁcant reduction in infarct mortality by aspirin and resulted in the ﬁrst ofﬁcial guideline recommendation of aspirin use in these patients .
V. Mosby Company, St. Louis, MO, pp. 417–424. , Zahradnicek, M. et al. (1992) Simultaneous high-performance liquid chromatographic determination of salicylates in whole blood, plasma and isolated erythrocytes. Journal of Chromatography, 584, 221–228. , Jehnich, D. and Grobecker, H. (1996) Simultaneous determination of acetylsalicylic acid and salicylic acid in human plasma by high-performance liquid chromatography. Journal of Chromatography B, 677, 172–177. 81 Trinder, P. (1954) Rapid determination of salicylate in biological ﬂuids.
Acetylsalicylic Acid by Karsten Schrör